Pilot ejected when small airplane dives near Chattanooga; search under way

By Gil Aegerter, Staff Writer, NBC News

A student pilot was ejected from a small aircraft above an area east of Chattanooga, Tenn., in a freak accident Friday evening, and authorities were searching for him.

The accident occurred when the owner of the Zodiac 601XL plane was taking lessons from an instructor, NBC station WRCB of Chattanooga reported, citing police. A malfunction caused the plane to nose dive and the canopy flew open -- and neither man was wearing a seat belt, WRCB reported.

The accident occurred at about 2,500 feet,?the Chattanooga Times Free Press reported.?

The instructor was able to land the aircraft back at Collegedale Municipal Airport, operations manager Chris Hancock confirmed to NBC News. He directed further questions to a Collegedale police spokesman who could not immediately be reached.

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A ground search was under way in Bradley County, WRCB said. The Times Free Press said the owner-pilot had a cell phone with him and rescuers were pinging it in an attempt to find him.

Neither of the men was identified publicly by authorities.

WRCB said the plane had been owned by a man killed in a December crash and then was sold to the current owner, described as an experienced pilot who wanted more training in the Zodiac.

The Zodiac 601XL is a single-engine kit aircraft offered for home builders. Its two seats are side by side under a large domed canopy.

?

This story was originally published on Fri Mar 29, 2013 9:18 PM EDT

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Famous People Tend to Stay Famous

Discovered:?Get used to Bieber and Kardashian;?a human/Neanderthal love child; DNA tests could predict cancer risks; the intuition of rats.

RELATED: Just a Few Facebook Likes Can Reveal Sexual Orientation

Famous people tend to stay famous. Pop artist Andy Warhol once declared that everyone, at some some point in the future, "would be world-famous for 15?minutes." But according to two professors ? one at McGill, the other at Stony Brook ??true fame is everlasting: "Contrary to popular belief, the people who become truly famous, stay famous for decades." The pair's paper shows that, despite our animosity toward the super-famous ? think Justin Bieber or Kim Kardashian ? they're pretty much here to stay. Why? The authors suggest fame is something of a self-fulfilling prophecy: "Both media and audiences are trapped in a self-reinforcing equilibrium where they must continue to devote attention, airtime, and newspaper space to the same old characters because everyone else does so as well." [American Sociological Review]

RELATED: There's a Two-Headed Bull Shark

Skeletal remains indicate a human/Neanderthal hybrid. We know all about Neanderthals ? a human-like ape species that inhabited west-central Asia and Europe hundreds of thousands of years ago. But until now we didn't know if they ever successfully bred with ancient humans. A skeleton recently discovered in Italy, however, indicates that that at least one female Neanderthal was able to mate with a male human. Still, this doesn't that the populations converged: "Although the hybridization between the two hominid species likely took place, the Neanderthals continued to uphold their own cultural traditions [which] suggests that the two populations did not simply meet, mate and merge into a single group." [NBC Science]

RELATED: Babies Are Evil, Just Like Us

DNA markers portend risk of cancer. A simple test of one's genes could one day predict your risk of cancer. That's the takeaway from a study of 200,000 individuals which indicates that certain markers embedded in one's DNA are routinely associated with a pronounced risk of cancer. It's not so much each marker that's important ? it's the number of them and pattern they form that could indicate a higher propensity to develop cancer. Even though the routine use of these markers is still far out in the future, the medical application is already obvious: "Under certain assumptions, a gene test using all known markers could reduce the number of mammograms and PSA tests by around 20 percent, with only a small cost in cancer cases missed." [Associated Press]

RELATED: Humans Descended from a Tiny Worm

You should trust your intuition. Is pondering useless? In rats, at least, it seems so. A group of researchers in Portugal found that the rodents performed equally well on a series of tasks when given a short time and a long time to decide. "When rats were challenged with a series of perceptual decision problems, their performance was just as good when they decided rapidly as when they took a much longer time to respond. Despite being encouraged to slow down and try harder, the subjects of this study achieved their maximum performance in less than 300 milliseconds." It's yet to be seen whether the results bear on the intuitive faculties of the human race. The researchers are optimistic, though: "Decision-making is not a well-understood process, but it appears to be surprisingly similar among species," one said. [Neuron]

Source: http://news.yahoo.com/famous-people-tend-stay-famous-221855253.html

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Controversial worm keeps its position as progenitor of humankind

Mar. 27, 2013 ? Researchers are arguing about whether or not the Xenoturbella bocki worm is the progenitor of humankind. But new studies indicate that this is actually the case.

Swedish researchers from the University of Gothenburg and the Gothenburg Natural History Museum are involved in the international study. The results have been published in Nature Communications.

The Xenoturbella bocki worm is a one-centimetre long worm with a simple body plan that is only found regularly by the west coast of Sweden. The worm lacks a brain, sexual organs and other vital organs.

Zoologists have long disagreed about whether or not the Xenoturbella bocki worm holds a key position in the animal tree of life. If it does have a key position, it is very important for the understanding of the evolutionary development of organs and cell functions, such as stem cells, for example. The question is therefore not only important in the field of biology, but also for potential biomedical applications.

"It's absolutely fantastic that one of the key evolutionary organisms in the animal kingdom lives right on the doorstep of the University of Gothenburg's Centre for Marine Research. And this is actually the only place in the whole world where you can do research on the creature," says Matthias Obst from the Department of Biological and Environmental Sciences at the University of Gothenburg.

Genetic studies indicate that the Xenoturbella bocki worm belongs to the group of deuterostomes, the exclusive group to which human's belongs.

"So maybe we're more closely related to the Xenoturbella bocki worm, which doesn't have a brain, than we are to lobsters and flies, for example," says Matthias Obst.

Even though the worm does not particularly resemble man, development biologists have referred to the fact that the early embryonic development of the worm may display similarities with the group to which man belongs. But the problem has been that no one has previously been able to see the development of the creature.

But now a group of researchers at the Sven Lov?n Centre for Marine Sciences and the Gothenburg Natural History Museum have succeeded in doing what no one else has done before: to isolate newly born little Xenoturbella bocki worms.

"And these new-born worms revealed absolutely no remnants at all of advanced features! Instead, they exhibit similarities with quite simple, ancient animals such as corals and sponges," says Matthias Obst.

The studies also reveal the value of the University of Gothenburg's marine stations for important basic research.

"The Lov?n Centre at the University of Gothenburg is the only place in the whole world where you can study this paradoxical animal (in Swedish called 'Paradox worm'). That's one reason why researchers come from all over the world to Gullmarsfjorden to solve one of the great mysteries in the evolution of animal life," says Matthias Obst.

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Story Source:

The above story is reprinted from materials provided by University of Gothenburg, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Hiroaki Nakano, Kennet Lundin, Sarah J. Bourlat, Maximilian J. Telford, Peter Funch, Jens R. Nyengaard, Matthias Obst, Michael C. Thorndyke. Xenoturbella bocki exhibits direct development with similarities to Acoelomorpha. Nature Communications, 2013; 4: 1537 DOI: 10.1038/ncomms2556

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/fOAdM4cxzag/130327103039.htm

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Cypriot banks set to reopen after 12 days -- but customers can only withdraw $383 each

Yannis Behrakis / Reuters

A staff member of Laiki Bank, which is to be liquidated, tries to calm customers as the branch in Nicosia prepares to open.

By Ian Johnston, Staff Writer, NBC News

Banks on the tax haven of Cyprus opened Thursday for the first time in 12 days amid the island's continuing financial crisis.

Strict limits on the amount of money that could be withdrawn have been imposed ? people will be able to withdraw 300 euros ($383) a day and no checks will be cashed ? amid fears of a run on the banks.

Account holders showed up hours before the banks were due to open to get in line.

Early indications were that there was no mass rush to withdraw cash, with just 13 people waiting outside one large Bank of Cyprus branch on the island as it opened at noon local time (6 a.m. ET). They were surrounded by a scrum of journalists.

?We need only from you cooperation, understanding and please patience,? the manager of the branch said before opening.

However a small crowd of people did press against the doors of a branch of Laiki Bank, which is being liquidated. CNBC sources estimate those with more than 100,000 euros (about $128,000) in accounts in Laiki Bank could lose 40 to 70 percent of their deposits.

During the banking shutdown, people could only withdraw 100 euros (about $127) a day from the country's two biggest banks, using ATMs.?Most who lined up for the opening Thursday were elderly people and those without ATM cards.?

Deposits above 100,000 euros with the Bank of Cyprus will be frozen and 40 percent of each account will be converted into bank stock. Accounts in both banks with balances under 100,000 euros will be fully protected.

A previous proposal to take less from all bank accounts?was vetoed by the Cypriot parliament.

The country is seeking to meet the terms of a bailout from the European Union of 10 billion euros ($12.9 billion) and, in order to raise enough funds to meet strict conditions imposed by the EU, it is preparing to take money from bank accounts.

Ahead of the banks? reopening, money was flown into the island and guards were seen delivering cash to banks in armored vehicles.

The banks were due to close at 6 p.m. local time (12 p.m. ET).

There was some relief on the island that the banks were finally opening again, but this was mixed with fear about what could happen.

The banks in Cyprus are set to reopen after days of being closed as a measure to prevent a run on deposits during the country's financial crisis. Millions in cash is on the move tonight as people camped out in expectation. ITV's Emma Murphy reports

'Slow death'
Yorgos Georgiou, who owns a dry cleaning business in Nicosia, told Reuters that "finally people's mood will be lifted and we can start to trust the system again."

But he added: "I'm worried about the poor kids working in the cashiers today, because people might vent their anger at them. You can't predict how people will react after so many days."

Kostas Nikolaou, a 60-year-old retiree, told Reuters that the uncertainty of the past two weeks had been "like a slow death."

"How can they tell you that you can't access your own money in the bank? It's our money, we are entitled to it,? he added.

The country?s president, Nicos Anastasiades, has described the bailout deal as ?painful? but essential.

However, Nobel laureate economist Christopher Pissarides said it was ?extremely unfair to the little guy.?

?For the first time in the euro zone, depositors are (being) asked to bail out failing banks," he said. "Now that used to be the case in the 1930s, especially United States (and) caused big bank runs. It has been decided since then that we shouldn?t allow that to happen again.?

As Cyprus celebrates its Independence Day, the ?government is defending the last-minute bailout deal it's negotiated with the European Union. This means shutting down the country's second biggest bank, with big savers facing ?losses. ?ITV's Emma Murphy reports.

Among other controls, the island's central bank will review all commercial transactions over 5,000 euros and scrutinize transactions over 200,000 euros on an individual basis, Reuters reported. People leaving Cyprus can take only 1,000 euros with them. An earlier draft of the decree had put the figure at 3,000.

Reuters summed up the situation facing the island:

With just 860,000 people, Cyprus has about 68 billion euros in its banks - a vastly outsized financial system that attracted deposits from foreigners as an offshore haven but foundered after investments in neighboring Greece went sour.

The European Union and International Monetary Fund concluded that Cyprus could not afford a rescue unless it imposed losses on depositors, seen as anathema in previous euro zone bailouts.?The bailout looks set to push Cyprus deeper into an economic slump, shrink the banking sector and cost thousands of jobs.

European leaders said the bailout deal averted a chaotic national bankruptcy that might have forced Cyprus out of the euro.

Many Cypriots say the deal was foisted upon them by Cyprus's partners in the 17-nation euro zone within the European Union, and some have taken to the streets to vent their frustration.

CNBC's Michelle Caruso-Cabrera and Katie Slaman, and Reuters contributed to this report.

Related:

Cypriots fear run on banks as branches prepare to reopen

Cypriots: Hope, but also fear they 'will be like slaves' to Russia

EU to Cypriots: Let us raid your savings or no bailout

This story was originally published on Thu Mar 28, 2013 4:52 AM EDT

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Cancer biologists find DNA-damaging toxins in common plant-based foods

Mar. 27, 2013 ? In a laboratory study pairing food chemistry and cancer biology, scientists at the Johns Hopkins Kimmel Cancer Center tested the potentially harmful effect of foods and flavorings on the DNA of cells. They found that liquid smoke flavoring, black and green teas and coffee activated the highest levels of a well-known, cancer-linked gene called p53.

The p53 gene becomes activated when DNA is damaged. Its gene product makes repair proteins that mend DNA. The higher the level of DNA damage, the more p53 becomes activated.

"We don't know much about the foods we eat and how they affect cells in our bodies," says Scott Kern, M.D., the Kovler Professor of Oncology and Pathology at the Johns Hopkins University School of Medicine. "But it's clear that plants contain many compounds that are meant to deter humans and animals from eating them, like cellulose in stems and bitter-tasting tannins in leaves and beans we use to make teas and coffees, and their impact needs to be assessed."

Kern cautioned that his studies do not suggest people should stop using tea, coffee or flavorings, but do suggest the need for further research.

The Johns Hopkins study began a year ago when graduate student Samuel Gilbert, working in Kern's laboratory, noted that a test Kern had developed to detect p53 activity had never been used to identify DNA-damaging substances in food.

For the study, published online February 8 in Food and Chemical Toxicology, Kern and his team sought advice from scientists at the U.S. Department of Agriculture about food products and flavorings. "To do this study well, we had to think like food chemists to extract chemicals from food and dilute food products to levels that occur in a normal diet," he says.

Using Kern's test for p53 activity, which makes a fluorescent compound that "glows" when p53 is activated, the scientists mixed dilutions of the food products and flavorings with human cells and grew them in laboratory dishes for 18 hours.

Measuring and comparing p53 activity with baseline levels, the scientists found that liquid smoke flavoring, black and green teas and coffee showed up to nearly 30-fold increases in p53 activity, which was on par with their tests of p53 activity caused by a chemotherapy drug called etoposide.

Previous studies have shown that liquid smoke flavoring damages DNA in animal models, so Kern's team analyzed p53 activity triggered by the chemicals found in liquid smoke. Postdoctoral fellow Zulfiquer Hossain tracked down the chemicals responsible for the p53 activity. The strongest p53 activity was found in two chemicals: pyrogallol and gallic acid. Pyrogallol, commonly found in smoked foods, is also found in cigarette smoke, hair dye, tea, coffee, bread crust, roasted malt and cocoa powder, according to Kern. Gallic acid, a variant of pyrogallol, is found in teas and coffees.

Kern says that more studies are needed to examine the type of DNA damage caused by pyrogallol and gallic acid, but there could be ways to remove the two chemicals from foods and flavorings.

"We found that Scotch whiskey, which has a smoky flavor and could be a substitute for liquid smoke, had minimal effect on p53 activity in our tests," says Kern.

Liquid smoke, produced from the distilled condensation of natural smoke, is often used to add smoky flavor to sausages, other meats and vegan meat substitutes. It gained popularity when sausage manufacturers switched from natural casings to smoke-blocking artificial casings.

Other flavorings like fish and oyster sauces, tabasco and soy sauces, and black bean sauces showed minimal p53 effects in Kern's tests, as did soybean paste, kim chee, wasabi powder, hickory smoke powders and smoked paprika.

Funding for the study was provided by the National Institutes of Health's National Cancer Institute (CA62924) and the Everett and Marjorie Kovler Professorship in Pancreas Cancer Research.

In addition to Kern, Gilbert and Hossain, other scientists involved in the research include Kalpesh Patel, Soma Ghosh, and Anil Bhunia from Johns Hopkins.

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Story Source:

The above story is reprinted from materials provided by Johns Hopkins Medicine, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. M. Zulfiquer Hossain, Samuel F. Gilbert, Kalpesh Patel, Soma Ghosh, Anil K. Bhunia, Scott E. Kern. Biological clues to potent DNA-damaging activities in food and flavoring. Food and Chemical Toxicology, 2013; 55: 557 DOI: 10.1016/j.fct.2013.01.058

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/rIaA_10aDzM/130327163302.htm

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Feminist Explorations of Knowledge: Present and ... - sociology@sau

Sociology Seminar Series 2013 Presents

Panel

Discussion

Feminist Explorations of Knowledge: Present and Future of Engendered Anthropology

Through the historical trajectories vis--?a--?vis waves of women?s movements, the feminist inquiries have made it possible to recon with a host of issues, categories and political possibilities of change. Meanwhile, regional varieties of feminism have also emerged adding novel dimensions to anthropological attempts at knowledge production. This panel debates the conventional and recent orientations in feminist approaches in anthropological studies.

Panelists:

Ravinder Kaur

Professor, Indian Institute of Technology, Delhi

Rajni Palriwala
Professor,Department of Sociology, University of Delhi

Gitika Bapana,

Research Scholar, University of Delhi

Chair:

Mary E? John
Senior Fellow and Director, Center for Women?s Development Study, Delhi

Discussant:

Mallika Shakya & Dev N Pathak,

Department of Sociology, SAU

Rapporteur:

Manoj Kumar Dhakal
MA Program in Sociology, SAU

Date and time :
3 April 2013; 02.15 pm

Venue:
FSI Hall, South Asian University, Akbar Bhawan, Chanakyapuyri, New Delhi

All are Welcome

(Please have your mobile phones switched off? during proceedings)

Source: http://sociology-sau.blogspot.com/2013/03/feminist-explorations-of-knowledge.html

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Final Fantasy V arrives on iOS, is unlikely to be the last

A touch iteration of the once SNES-bound Final Fantasy V has now appeared on the iTunes App Store, with a softer graphical lick, some new job classes (Gladiator, Cannoneer, Oracle and Necromancer) and an obligatory extra boss to test your leveling-up skills against. The price of four new costumes for your meteor-riding protagonists? Just shy of $16. Saving the world was never going to be cheap easy.

Filed under: Cellphones, Gaming, Tablets, Mobile

Comments

Via: Destructoid

Source: Final Fantasy V (iTunes)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/iJswQ_rou2o/

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N.D. readies for legal battles on abortion

BISMARCK, N.D. (AP) ? North Dakota Gov. Jack Dalrymple said his decision to sign strict new abortion laws, including the nation's toughest restriction on the procedure, was not based on "any religious belief or personal experience" and that he believes legislators have a right to ask such questions about abortion restrictions.

The Republican governor signed three anti-abortion measures on Tuesday ? including one banning abortions as early as six weeks into a pregnancy, or when a heartbeat can be detected. By doing so, Dalrymple positioned his oil-rich state as a primary battleground in the decades-old fight over abortion rights.

Within minutes of signing the laws, unsolicited donations began pouring into the state's lone abortion clinic to help opponents prove the new laws are unconstitutional. The governor urged lawmakers to set aside cash for an inevitable legal challenge.

"Although the likelihood of this measure surviving a court challenge remains in question, this bill is nevertheless a legitimate attempt by a state legislature to discover the boundaries of Roe v. Wade," Dalrymple said in a statement, referring to the 1973 U.S. Supreme Court ruling that legalized abortion up to until a fetus is considered viable ? usually at 22 to 24 weeks.

In an interview later Tuesday, Dalrymple told The Associated Press that the courts opened the door for a challenge by picking a specific moment in the timeline of gestation. He also said he studied the fetal heartbeat bill and "educated myself on the history and legal aspects as best I could. My conclusion is not coming from any religious belief or personal experience."

Dalrymple seemed determined to open a legal debate on the legislation, acknowledging the constitutionality of the measure was an open question. He asked the Legislature to set aside money for a "litigation fund" that would allow the state's attorney general to defend the measure against lawsuits.

He said he didn't know how much the likely court fight would cost. But, he said money wasn't the issue.

"The Legislature has decided to ask these questions on additional restrictions on abortions, and I think they have the legitimate right to ask those questions," he said.

He also signed into law measures that would makes North Dakota the first state to ban abortions based on genetic defects such as Down syndrome and require a doctor who performs abortions to be a physician with hospital-admitting privileges.

Lawmakers endorsed a fourth anti-abortion bill last week that would ban abortions after 20 weeks of pregnancy based on the disputed premise that fetuses feel pain at that point. The governor stopped short of saying he would sign it, but said: "I've already signed three bills. Draw your own conclusion."

The signed measures, which take effect Aug. 1, are fueled in part by an attempt to close the Red River Women's Clinic in Fargo ? the state's only abortion clinic.

Tammi Kromenaker, the clinic's director, called the legislation "extreme and unconstitutional" and said Dalrymple "awoke a sleeping giant" by approving it. The clinic, which performs about 3,000 abortions annually, was accepting cash donations and continued to take appointments Tuesday, she said.

"First and foremost, abortion is both legal and available in North Dakota," she said. "But anytime abortion laws are in the news, women are worried about access."

The Center for Reproductive Rights announced Tuesday that it has committed to challenging the fetal heartbeat bill on behalf of the clinic. The New York-based group already represented the clinic for free in a lawsuit over a 2011 law banning the widely accepted use of a medication that induces abortion. A judge has temporarily blocked enforcement of the law, and a trial is slated for April in Fargo.

Attorney General Wayne Stenehjem told the AP that lawyers from his office would defend any lawsuits that arise but an increase to the agency's budget would likely be necessary. He did not have a dollar amount.

The state has spent about $23,000 in legal costs to date defending the 2011 legislation, according to agency records obtained by the AP.

Julie Rikelman, litigation director for the Center for Reproductive Rights, said the group has provided three attorneys to argue that case. But in the recent round of legislation, the fetal heartbeat measure is the priority because it would effectively ban abortion in the state, she said.

"The impact is very, very clear," she said. "It would have an immediate and very large impact on the women in North Dakota."

Rikelman said the center also would support the clinic in other litigation, if need be and at no cost.

Kromenaker said other states have spent millions of dollars defending legislation, if the case reaches the nation's highest court. Rikelman said it's impossible to put a dollar amount on the impending legal fight in North Dakota.

"Litigation is so unpredictable," she said. "It could be very quick with a ruling in our favor."

North Dakota's law, since it would ban most abortions as early as six weeks into a pregnancy, goes further than a bill approved earlier this month in Arkansas that establishes a 12-week ban ? prohibiting them when a fetal heartbeat can be detected using an abdominal ultrasound. That ban is scheduled to take effect 90 days after the Arkansas Legislature adjourns.

A fetal heartbeat can generally be detected earlier in a pregnancy using a vaginal ultrasound, but Arkansas lawmakers balked at requiring women seeking abortions to have the more invasive imaging technique.

North Dakota's legislation doesn't specify how a fetal heartbeat would be detected.

Doctors performing an abortion after a heartbeat is detected could face a felony charge punishable by up to five years in prison and a $5,000 fine. Women having an abortion would not face charges.

The legislation to ban abortions based on genetic defects also would ban abortion based on gender selection. The Guttmacher Institute, which tracks abortion laws throughout the country, says Pennsylvania, Arizona and Oklahoma also have laws outlawing abortion based on gender selection.

The Republican-led North Dakota Legislature has endorsed a spate of anti-abortion Legislation this year. North Dakota lawmakers moved last week to outlaw abortion in the state by passing a resolution defining life as starting at conception, essentially banning abortion in the state. The measure is likely to come before voters in November 2014.

Dalrymple attended a groundbreaking ceremony Tuesday for a new diesel refinery in western North Dakota and made no public appearance to explain his signing of the abortion legislation.

Source: http://news.yahoo.com/nd-gears-legal-dispute-abortion-laws-222233847.html

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Gay NFL Player May Come Out Soon: Report (VIDEO)

HuffPost Live:

CBS Sports' Mike Freeman reports that "Based on interviews over the past several weeks with current and former players, I'm told that a current gay NFL player is strongly considering coming out publicly within the next few months," adding that the player intends to continue playing in the league after making the announcement.

HuffPost Sports Editor Chris Greenberg joined HuffPost Live's Jacob Soboroff to talk about the report and what it could mean for the NFL.

Read the whole story at HuffPost Live

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Source: http://www.huffingtonpost.com/2013/03/25/gay-nfl-player-may-come-out-report_n_2952277.html

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Gene therapy may aid failing hearts

Mar. 25, 2013 ? In an animal study, researchers at the University of Washington show that it was possible to use gene therapy to boost heart muscle function. The finding suggests that it might be possible to use this approach to treat patients whose hearts have been weakened by heart attacks and other heart conditions.

Led by University of Washington (UW) Professor and Vice Chair of Bioengineering Michael Regnier and Dr. Chuck Murry, director of the Center for Cardiovascular Biology and co-director of the Institute for Stem Cell and Regenerative Medicine at UW, the study appears online today in the journal Proceedings of the National Academy of Sciences (PNAS).

Normally, muscle contraction is powered by a molecule, the nucleotide called Adenosine-5'-triphosphate (ATP). Other naturally occurring nucleotides can also power muscle contraction, but, in most cases, they have proven to be less effective than ATP.

In an earlier study of isolated muscle, however, Regnier, Murry and colleagues had found that one naturally occurring molecule, called 2 deoxy-ATP (dATP), was actually more effective than ATP in powering muscle contraction, increasing both the speed and force of the contraction, at least over the short-term.

In the new PNAS study, the researchers wanted to see whether this effect could be sustained. To do this, they used genetic engineering to create a strain of mice whose cells produced higher-than-normal levels of an enzyme called Ribonucleotide Reductase, which converts the precursor of ATP, adenosine-5'-diphosphate or ADP, to dADP, which, in turn, is rapidly converted to dATP.

"This fundamental discovery, that dATP can act as a 'super-fuel' for the contractile machinery of the heart, or myofilaments, opens up the possibility to treat a variety of heart failure conditions," Regnier said. "An exciting aspect of this study and our ongoing work is that a relatively small increase in dATP in the heart cells has a big effect on heart performance."

The researchers found that increased production of the enzyme Ribonucleotide Reductase increased the concentration of dATP within heart cells approximately tenfold, and even though this level was still less than one to two percent of the cell's total pool of ATP, the increase led to a sustained improvement in heart muscle function, with the genetically engineered hearts contracting more quickly and with greater force.

"It looks as though we may have stumbled on an important pathway that nature uses to regulate heart contractility," Murry added. "The same pathway that heart cells use to make the building blocks for DNA during embryonic growth makes dATP to supercharge contraction when the adult heart is mechanically stressed."

Importantly, the elevated dATP effect was achieved without imposing additional metabolic demands on the cells, suggesting the modification would not harm the cell's functioning over the long-term.

The finding, the authors write, suggest that treatments that elevate dATP levels in heart cells may prove to be an effective treatment for heart failure.

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The above story is reprinted from materials provided by University of Washington - Health Sciences, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Sarah G. Nowakowski, Stephen C. Kolwicz, Frederick Steven Korte, Zhaoxiong Luo, Jacqueline N. Robinson-Hamm, Jennifer L. Page, Frank Brozovich, Robert S. Weiss, Rong Tian, Charles E. Murry, and Michael Regnier. Transgenic overexpression of ribonucleotide reductase improves cardiac performance. PNAS, March 25, 2013 DOI: 10.1073/pnas.1220693110

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/F2dumpqeqr0/130326101618.htm

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My Meat With Selling And Purchasing Used Vehicles From Auctions ...

Reign of The Muscle Autos Back in the latter 1950s and the 1960s an auto revolution occurred with the huge motor firms in the business. The general public was hot on Muscle Autos . It took the country by force, where folk were getting these autos as swiftly as they might come out. The point of selling these electrical vehicle conversion kits is to give folks an opportunity to assemble their own automobile to be electrically-powered. The target was on functionality and practically than anything. Pros of automobile conversion suggest that if you are looking to convert your automobile to run on electricity, you must consider of transforming light autos only. You must also buy or take advantage of a web guide showing you how to change your automobile into an electrical automobile, so that you'll assemble the parts correctly, and avoid defective connections and flawed set-ups. The one place to get the biggest list, no matter the location are the internet sites partnered with the governing body and the departments which seize the assets.

There are 1 or 2 web sites of this sort and you need to be careful when you selected one. To get a life membership you are going to have to pay a tiny one time charge. The one thing you have got to do is get a membership on the right web site and then get thousands of grabbed autos prepared for auction. You'll definitely have competition for these rights but with careful bidding you can land yourself a good deal on your dream muscle auto. Http://www.Musclecars-forsale.com is a site that list muscle autos that are for sale on ebay, the list is updated numerous times daily so you're going to find the classic ride you are searching for. Check you local papers, visit online classified sites, Drive around your area, and check on ebay. You do not have to spend a massive amount to possess the muscle automobile of your dreams.

This entry was posted in Uncategorized and tagged automobile, automobile electrical, autos, car, muscle, muscle auto, muscle autos, web, web site on 03/25/2013 by blogging.

Source: http://www.carmencab.com/?p=127

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APNewsBreak: $1.7M penalty proposed in Exxon spill

	Essential News from The Associated Press

? ?Associated Press. All Rights Reserved.

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-03-25-Yellowstone%20Oil%20Spill-Violations/id-83699c0794c04824bb5c1a6fed721d28

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Carnegie Mellon's Kevin Zollman earns NSF award to investigate economics of science

Public release date: 26-Mar-2013
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Contact: Shilo Rea
shilo@cmu.edu
412-268-6094
Carnegie Mellon University

PITTSBURGHCarnegie Mellon University's Kevin Zollman has received a Faculty Early Career Development (CAREER) Award from the National Science Foundation (NSF) for his project "Incentives, Diversity and Scientific Problem Choice."

Zollman, an associate professor of philosophy in the Dietrich College of Humanities and Social Sciences, will use the five-year, $400,000 award to investigate the economics of science to further understand the relationship between scientists and the incentives they face to secure funding, publish papers and receive promotions. He will connect existing studies that use an economic methodology to understand problem choice in order to explore the effects of incentives in science. The results of his work will include tools developed to help scientific policymakers evaluate the effect of different incentive systems.

The CAREER Award is the NSF's most prestigious award designed to support junior faculty who exemplify the role of teacher-scholars through their outstanding research, excellent teaching and the integration of education and research within the context of their organization's missions.

"Kevin is without doubt one of the most talented young scholars in philosophy today and one of our most committed and effective teachers," said Richard Scheines, head of the Department of Philosophy. "I am delighted that the NSF has chosen to recognize him with such a prestigious award, and that the award will give him the time and resources needed to get deep into a great topic: how does the economic landscape within which science functions affect its ability to acquire knowledge efficiently."

Zollman joined the CMU faculty as the first Herbert Simon Postdoctoral Fellow of Scientific Philosophy in 2008. His research focuses on game theory, agent-based modeling and the philosophy of science. Currently, Zollman teaches at both the undergraduate and graduate level, including courses on Rational Choice, Philosophy of Economics and Social Epistemology.

###

For more information on Zollman, visit http://www.andrew.cmu.edu/user/kzollman/.

To learn more about the humanities at Carnegie Mellon, watch this video: http://youtu.be/DFdHcQN-Chs.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 26-Mar-2013
[ | E-mail | Share ]

Contact: Shilo Rea
shilo@cmu.edu
412-268-6094
Carnegie Mellon University

PITTSBURGHCarnegie Mellon University's Kevin Zollman has received a Faculty Early Career Development (CAREER) Award from the National Science Foundation (NSF) for his project "Incentives, Diversity and Scientific Problem Choice."

Zollman, an associate professor of philosophy in the Dietrich College of Humanities and Social Sciences, will use the five-year, $400,000 award to investigate the economics of science to further understand the relationship between scientists and the incentives they face to secure funding, publish papers and receive promotions. He will connect existing studies that use an economic methodology to understand problem choice in order to explore the effects of incentives in science. The results of his work will include tools developed to help scientific policymakers evaluate the effect of different incentive systems.

The CAREER Award is the NSF's most prestigious award designed to support junior faculty who exemplify the role of teacher-scholars through their outstanding research, excellent teaching and the integration of education and research within the context of their organization's missions.

"Kevin is without doubt one of the most talented young scholars in philosophy today and one of our most committed and effective teachers," said Richard Scheines, head of the Department of Philosophy. "I am delighted that the NSF has chosen to recognize him with such a prestigious award, and that the award will give him the time and resources needed to get deep into a great topic: how does the economic landscape within which science functions affect its ability to acquire knowledge efficiently."

Zollman joined the CMU faculty as the first Herbert Simon Postdoctoral Fellow of Scientific Philosophy in 2008. His research focuses on game theory, agent-based modeling and the philosophy of science. Currently, Zollman teaches at both the undergraduate and graduate level, including courses on Rational Choice, Philosophy of Economics and Social Epistemology.

###

For more information on Zollman, visit http://www.andrew.cmu.edu/user/kzollman/.

To learn more about the humanities at Carnegie Mellon, watch this video: http://youtu.be/DFdHcQN-Chs.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-03/cmu-cmk032613.php

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Official says US seeks Arab states for peace push

RAMALLAH, West Bank (AP) ? The U.S. is seeking to bring Arab countries into efforts to restart Israeli-Palestinian negotiations that broke down more than four years ago, a senior Palestinian official said Monday.

Also Monday, the Israeli government said it would resume regular transfers of millions of dollars in tax revenues it collects on behalf of the Palestinian Authority, a step bound to ease the self-rule government's protracted cash crisis.

The decision came just days after President Barack Obama met with Israeli Prime Minister Benjamin Netanyahu and Palestinian President Mahmoud Abbas during a visit to the region. Obama has said stabilizing the Palestinian Authority, which has buckled under mounting debt, is key to U.S. peace efforts.

However, there are wide gaps on the terms of renewing talks. The Palestinians say Israel must freeze settlement building on lands it captured in 1967 before any negotiations can resume. Israel says the issue of settlements can be addressed during negotiations.

Obama has sided with the Israeli view, and it is not clear how the U.S. can bring the Palestinians back to the table without a settlement freeze.

Arab countries are now being asked to help, said Yasser Abed-Rabbo, a top official in the Palestine Liberation Organization.

"U.S. efforts will increase in coming weeks and will include other Arab parties, such as Jordan and Egypt," Abed-Rabbo told Voice of Palestine radio, adding that an Arab League delegation is to visit Washington as part of these efforts.

However, he said there would be no flexibility on Palestinian demands for a settlement freeze.

"For us, the important thing is the substance, such as the full settlement freeze and the recognition of the 1967 borders," he said.

The Palestinians want a state in the West Bank, Gaza and east Jerusalem ? territories Israel captured in 1967 ? but are ready to negotiate border changes, provided the 1967 frontier is the baseline.

Palestinian officials say they cannot return to talks without such a clear framework, arguing that open-ended negotiations will simply provide diplomatic cover to Israel to keep expanding settlements.

"We fear they (the Israelis) would waste time by getting us into a bargaining process over details and steps here and there, and in this way would waste two to three years and then get us to wait for a new U.S. administration," Abed-Rabbo said.

Netanyahu has said he is willing to resume talks immediately. However, he has said he will not relinquish control over east Jerusalem and has refused to recognize the 1967 lines as a starting point for talks.

For 10 months during his previous term, Netanyahu curbed settlement building as part of a U.S. push to bring the Palestinians back to the table, but negotiations never got off the ground.

Successive Israeli governments have built dozens of settlements in the West Bank and east Jerusalem, now home to more than half a million Israelis. Israel withdrew from Gaza in 2005, dismantling almost two dozen settlements there, but sharply restricts access to the territory.

Palestinian negotiator Saeb Erekat said Sunday that the Palestinians would wait two to three months to see if a new U.S. push to restart talks will yield results.

Meanwhile, Netanyahu said he has instructed Finance Minister Yair Lapid to resume the monthly transfer of taxes and customs duties Israel collects on behalf of the Palestinian Authority.

The decision was announced on the eve of the Jewish holiday of Passover, and Israeli officials were not available to further comment.

Israel froze the transfers of about $100 million a month after a successful Palestinian bid in November to win U.N. recognition of a state of Palestine in the lands Israel captured in 1967. Israel has released some money since then, but not on schedule.

The office of Palestinian Prime Minister Salam Fayyad said it expects Israel will now transfer the money regularly.

The transfers are a key component of the Palestinian Authority's budget. In recent months, the self-rule government, which administers about 38 percent of the West Bank, has struggled to pay salaries of tens of thousands of civil servants, the backbone of the local economy, and repay its debt to the private sector.

Source: http://news.yahoo.com/official-says-us-seeks-arab-states-peace-push-155317484.html

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An update on Iran?s nuclear program (Powerlineblog)

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